Arsen Arakelyan

Space radiation (IR) from Solar Particle Events (SPE) and Galactic Cosmic Rays (GCR), also known as high charge and energy (HZE) IR, is a primary risk associated with deep-space missions. There are limited animal and human studies on the risk of cardiovascular disease (CVD) development due to space-IR. The cardiac effects induced by space-type IR, specifically simplified GCR simulated (simGCRsim)-IR, are yet to be discovered. We hypothesized that gamma (γ) and simGCRsim IR-induced biological ...

An increasing number of countries are investing efforts to exploit the human genome, in order to improve genetic diagnostics and to pave the way for the integration of precision medicine into health systems. The expected benefits include improved understanding of normal and pathological genomic variation, shorter time-to-diagnosis, cost-effective diagnostics, targeted prevention and treatment, and research advances. Despite the significance of such studies, there is a lack of comprehensive genomic ...

We have done a chemoinformatics analysis of more than 400,000 chemical compounds tested against human influenza A and B viruses, in which we showed the distribution of various chemical and physicochemical properties in relation to the antiviral activity of the compounds. We also identified compounds that demonstrated activity against the virus, but whose derivatives remain unstudied and therefore may serve as subjects for future research. We have also submitted another manuscript describing a new ...

We invite you to take part in the Annual Scientific and Practical Conference of the Interregional Public Organization of Molecular Geneticists in Oncology and Oncohematology (IPO MGO)

“Molecular Diagnostics in Oncology and Related Fields of Medicine,” which will be held on January 17–18, 2026, in Yerevan, Armenia.

The first IPO MGO conference was held in Yekaterinburg in 2022, the second in Saint Petersburg in 2023, and the third in Nizhny Novgorod in 2024. Each event brought together a large ...

DigitalLife aims at bringing together complementary Armenian and German competence of the project partners in three major areas: omics bioinformatics for health with single-cell omics resolution, the establishment of infrastructure for genomic data collection, analysis, and sharing, and the Research School offering a qualification program for young scientists. The research tasks include the development of pathway analysis and machine learning methods and software for single-cell omic data analysis, ...

This supplementary dataset contains complete results of the analysis of disease associated SNPs distribution across geographic regions.

1. SNP_SOM_all_populations.zip - an archive with the results of SOM-portrayal of geographical diversity of disease-associated SNPs

2. SNP_zoomSOM_armenians.zip - an archive with the results of SOM-portrayal of geographical diversity of disease-associated SNPs of selected populations from Europe, Middle East, Central-South Asia and Armenians.

Sequencing of SARS-CoV-2 provides essential information on viral evolution, transmission, and epidemiology. In this study, we performed whole-genome sequencing of SARS-CoV-2 using nanopore and Illumina short-read sequencing to describe the circulation of the virus lineage in Armenia.

This dataset contains Nextstrain configuration files, the auspice JSON file, BEAST output logs, and trees files, and resulting log and tree files as well as R scripts and data files used in phylogenetic and functional ...

Aligned sequencing data is available in the NCBI Sequence Read Archive (SRA, https://www.ncbi.nlm.nih.gov/sra/) under accession SRP095082. Variants were called using GATK HaplotypeCaller (version 3.6). After joint performing joint genotyping multi-sample vcf file was generated. Next, SNPs and indels were extracted into two different vcf files and specific set of filters were applied for each case.

This is the submission accompanying raw result files for multiple-layer SOM (ml-SOM) analysis for the paper "Transcriptome patterns of BRCA1- and BRCA2- mutated breast and ovarian cancers".

The dataset contains the results of the ml-SOM analysis of RNA-sequencing data from TCGA-OV (ovarian cancer) and TCGA-BRCA (breast cancer) projects.

The dataset is organized as follows:

Folder "12.BC.40 - Results" - ml-SOM analysis of TCGA-BRCA (breast cancer) dataset Folder "12.OV.40 - Results" - ml-SOM ...

The dataset contains raw and intermediated files, and scripts required to reproduce the results associated with the manuscript "Assigning transcriptomic subtypes to CLL samples using nanopore RNA-sequencing and self-organizing maps". Here, we demonstrate that integrating publicly available short-read data with in-house generated ONT data, along with the application of machine learning approaches, enables the characterization of the CLL transcriptome landscape, the identification of clinically ...

oposSOM is a comprehensive, machine learning based open-source data analysis software combining functionalities such as diversity analyses, biomarker selection, function mining, and visualization. These functionalities are now available as interactive web-browser application for a broader user audience interested in extracting detailed information from high-throughput omics data sets pre-processed by oposSOM. It enables interactive browsing of single-gene and gene set profiles, of molecular ...

The Pathway Signal Flow (PSF) toolkit is an R package designed for pathway editing and signal flow analysis. It enables users to perform PSF analysis on functional -omics data, facilitating the study of signaling pathways in various biological contexts.

Key Features:

• Pathway Editing: Allows customization and editing of biological pathways to suit specific research needs.

• Signal Flow Calculation: Computes signal flow within pathways based on gene expression data, aiding in the ...

KEGG pathway database is a collection of manually drawn pathway maps representing current knowledge on molecular interaction and reaction networks, accompanied with KGML (KEGG pathway xml format) files for automatic computational analyses and modeling of metabolic and signaling networks. In a KGML file the pathway is represented as a graph object with entry elements (gene products, compounds, pathways) as its nodes, and relations between elements as edges. However, in most cases there is a lack ...

Arsen Arakelyan

Bioinformatics Tools for Precision Medicine

Institute of Molecular Biology NAS RA, Yerevan, Armenia

10:10 - 10:30

Moderators: R. Zakharyan, M. Filipenko

Section 1

Speaker - Arsen Arakelyan

Institute of Biomedicine and Pharmacy RAU, Institute of Molecular Biology NAS, Yerevan, Armenia

The “Low dose radiation risks: present research and future perspectives” Advanced Research Workshop is a NATO (North Atlantic Treaty Organization)-sponsored workshop organized by the McMaster University (Canada) and Institute of Molecular Biology NAS RA (National Academy of Sciences of Republic of Armenia) which offers a unique opportunity to learn about new discoveries and exchange experience with professionals in the field of radioecology, radiobiology, country-specific regulatory agencies, ...

Molecular Diagnostics in Oncology and Related Fields of Medicine

Date: January 17–18, 2026, Yerevan, Armenia

16-18 OCTOBER 2025 YEREVAN, ARMENIA

AGENDA

• Cell Technologies
• Regenerative Medicine
• Intelligent Data Science
• Synthetic Biology
• Postgenome
• Research & Development

OCTOBER 5-10, 2025 YEREVAN, ARMENIA

Patient-specific induced pluripotent stem cells (iPSCs) are reprogrammed somatic cells derived from individual patients through the expression of key transcription factors (e.g., OCT4, SOX2, KLF4, and c-MYC). These cells exhibit pluripotency, allowing them to differentiate into various cell types and serve as in vitro models for studying disease mechanisms, drug screening, and regenerative medicine.

The archive contains presentation slides and recorded talks from the Third International Congress "CRISPR-2025".

The archive contains presentation slides and recorded talks from the "International Summit in Immuno-Oncology".

The archive contains presentation slides and recorded talks from the conference "Molecular Diagnostics in Oncology and Related Fields of Medicine".

Archive contains presentation slides and recorded talks of the “Low dose radiation risks: present research and future perspectives” Advanced Research Workshop.