Arsen Arakelyan

This project focuses on studies around brain disorders and ageing.

Background: Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the type, timing and level of metal exposure and DNA methylation is not yet clear. The human epidemiologic and the toxicologic animal model studies provide strong evidence of metal exposure related DNA methylation changes, and, consequently alterations in gene expression, in metabolic, genetic and signal transduction pathways and their functions. ...

Space radiation (IR) from Solar Particle Events (SPE) and Galactic Cosmic Rays (GCR), also known as high charge and energy (HZE) IR, is a primary risk associated with deep-space missions. There are limited animal and human studies on the risk of cardiovascular disease (CVD) development due to space-IR. The cardiac effects induced by space-type IR, specifically simplified GCR simulated (simGCRsim)-IR, are yet to be discovered. We hypothesized that gamma (γ) and simGCRsim IR-induced biological ...

This dataset provides data necessary to replicate the results of the time-perturbation analysis of gene expression in health and mental disorders. The corresponding code is available in the GitHub repository under the https://github.com/susieavagyan/BrainExp-TemporalDynamics link.

This dataset provides data necessary to replicate the results of the time-perturbation analysis of gene expression in health and mental disorders. The corresponding code is available in the GitHub repository under the https://github.com/susieavagyan/BrainExp-TemporalDynamics link.

KEGG pathway database is a collection of manually drawn pathway maps representing current knowledge on molecular interaction and reaction networks, accompanied with KGML (KEGG pathway xml format) files for automatic computational analyses and modeling of metabolic and signaling networks. In a KGML file the pathway is represented as a graph object with entry elements (gene products, compounds, pathways) as its nodes, and relations between elements as edges. However, in most cases there is a lack ...