Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics
OverviewIn this project genetic engineering and functional genomics approaches will be used to describe molecular mechanisms of FMF. Using DNA/RNA samples obtained from FMF patients and healthy subjects MEFV nanopore gene sequencing will be performed to identify genetic variants and possibly find novel putative functional variants. The impact of genetic variants on transcriptome landscape will be studies by RNA-sequencing using nanopore sequencing device. Based on MEFV sequencing data and patients clinical records FMF patients to develop iPSCs will be selected. Characterizing of iPSCs with whole exome sequencing together with the data obtained during project implementation will enrich current knowledge on molecular mechanisms of FMF.
Programme: Cellular basis of diseases
SEEK ID: https://armlifebank.am/projects/7
Public web page: Not specified
Organisms: Human
ArmLifeBank PALs: Roksana Zakharyan
Project start date: 1st Sep 2021
Project end date: 31st Aug 2024
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Projects: Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue, Functional Genomics of Vine, Molecular Profiling of Cancer Metastases, Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Mental disorders and aging brain, Omics-Based Insights into Human Long-Term Exposure to Environmental Metals, Biological pathway activity analysis, ML approaches for omic data analysis, Tools for Telomere Biology, Armenian Wine Genome Program, Molecular characterization of cancers with long-read RNA sequencing, Low dose radiation risks: present research and future perspectives
Institutions: Institute of Molecular Biology NAS RA, Armenian Bioinformatics Institute
https://orcid.org/0000-0002-6851-1056
Cellular dysfunction, the fundamental basis of all human diseases, underpins the pathophysiology of numerous disorders. This program presents a overview of research initiatives focused on advancing human health through the development of diagnostic, preventive, and therapeutic strategies. These projects are conducted in collaboration with multiple research institutions and are supported by diverse grant funding mechanisms.
Projects: Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Development of induced pluripotent stem cells bank of patients with Familial Mediterranean Fever
Web page: Not specified
Abstract (Expand)
Authors: Varduhi Hayrapetyan, Lana Karapetyan, Lilit Ghukasyan, Sofi Atshemyan, Hovsep Ghazaryan, Valentina Vardanyan, Vahan Mukuchyan, Arsen Arakelyan, Roksana Zakharyan
Date Published: 2nd Dec 2024
Publication Type: Journal
Abstract (Expand)
Authors: Lilit Ghukasyan, Gisane Khachatryan, Tamara Sirunyan, Arpine Minasyan, Siras Hakobyan, Andranik Chavushyan, Varduhi Hayrapetyan, Hovsep Ghazaryan, Gevorg Martirosyan, Gohar Mkrtchyan, Valentina Vardanyan, Vahan Mukuchyan, Ashot Davidyants, Roksana Zakharyan, Arsen Arakelyan
Date Published: 29th Nov 2024
Publication Type: Journal
Abstract (Expand)
Authors: Elena V. Grigor’eva, Lana V. Karapetyan, Anastasia A. Malakhova, Sergey P. Medvedev, Julia M. Minina, Varduhi H. Hayrapetyan, Valentina S. Vardanyan, Suren M. Zakian, Arsen Arakelyan, Roksana Zakharyan
Date Published: 1st Jun 2024
Publication Type: Journal
Abstract (Expand)
Authors: Elena V. Grigor’eva, Anastasia A. Malakhova, Lilit Ghukasyan, Varduhi Hayrapetyan, Sofi Atshemyan, Valentina Vardanyan, Suren M. Zakian, Roksana Zakharyan, Arsen Arakelyan
Date Published: No date defined
Publication Type: Journal
Patient-specific induced pluripotent stem cells (iPSCs) are reprogrammed somatic cells derived from individual patients through the expression of key transcription factors (e.g., OCT4, SOX2, KLF4, and c-MYC). These cells exhibit pluripotency, allowing them to differentiate into various cell types and serve as in vitro models for studying disease mechanisms, drug screening, and regenerative medicine.
Sample Name (String) *, Type (String) *, Condition (String) *, Link (String) , Location (String)
Not specified
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
