Human
Strain details
| Name | Provider name | Provider's strain ID | Genotypes | Phenotypes | Synonym | Comments | Based on |
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Related items
Cellular dysfunction, the fundamental basis of all human diseases, underpins the pathophysiology of numerous disorders. This program presents a overview of research initiatives focused on advancing human health through the development of diagnostic, preventive, and therapeutic strategies. These projects are conducted in collaboration with multiple research institutions and are supported by diverse grant funding mechanisms.
Projects: Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Development of induced pluripotent stem cells bank of patients with Familial Mediterranean Fever
Web page: Not specified
Cellular dysfunction, the fundamental basis of all human diseases, underpins the pathophysiology of numerous disorders. This program presents a overview of research initiatives focused on advancing human health through the development of diagnostic, preventive, and therapeutic strategies. These projects are conducted in collaboration with multiple research institutions and are supported by diverse grant funding mechanisms.
Projects: Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Development of induced pluripotent stem cells bank of patients with Familial Mediterranean Fever
Web page: Not specified
This program is designed to encapsulate and facilitate research projects focusing on the intricate dynamics between genetic predispositions and environmental factors in the progression of chronic diseases, excluding cancer. This initiative aims to unravel the molecular mechanisms and pathways that underlie these diseases, thereby paving the way for targeted interventions and therapies.
Projects: Mental disorders and aging brain, Omics-Based Insights into Human Long-Term Exposure to Environmental Metals
Web page: Not specified
This program is designed to encapsulate and facilitate research projects focusing on the intricate dynamics between genetic predispositions and environmental factors in the progression of chronic diseases, excluding cancer. This initiative aims to unravel the molecular mechanisms and pathways that underlie these diseases, thereby paving the way for targeted interventions and therapies.
Projects: Mental disorders and aging brain, Omics-Based Insights into Human Long-Term Exposure to Environmental Metals
Web page: Not specified
This Programme offers a comprehensive summary of various projects focused on deciphering the intricate molecular mechanisms of cancer development, progression, and response to treatments, utilizing bioinformatics, computational biology, and machine learning. These are multi-laboratory efforts carried out across several research institutions, supported by various grant programs.
Projects: Molecular Profiling of Cancer Metastases, Molecular characterization of cancers with long-read RNA sequencing
Web page: Not specified
Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The human epidemiologic and the toxicologic animal model studies provide strong evidence of metal exposure related DNA methylation changes, and, consequently alterations in gene expression, in metabolic, genetic and signal transduction pathways and their functions. The current study is designed to investigate genome wide DNA methylation and transcriptomic changes induced by human chronic ...
Programme: Genes, Environment and Chronic Diseases
Public web page: Not specified
Start date: 1st Feb 2020
The aim of this project is to establish a bank of induced pluripotent stem cells from patients with Familial Mediterranean Fever (FMF) using cell reprogramming approaches for a more comprehensive study of disease molecular mechanisms. In Armenia, FMF prevalence is about 14-100 per 10,000 inhabitants, depending on the region. For the comprehensive research of the disease, it is necessary to have appropriate cell platforms that will contain pathogenic mutations of the FMF. Created stem cell bank ...
Programme: Cellular basis of diseases
Public web page: Not specified
Start date: 1st Mar 2025
End date: 1st Mar 2027
This project focuses on studies around brain disorders and ageing.
Programme: Genes, Environment and Chronic Diseases
Public web page: Not specified
In this project genetic engineering and functional genomics approaches will be used to describe molecular mechanisms of FMF. Using DNA/RNA samples obtained from FMF patients and healthy subjects MEFV nanopore gene sequencing will be performed to identify genetic variants and possibly find novel putative functional variants. The impact of genetic variants on transcriptome landscape will be studies by RNA-sequencing using nanopore sequencing device. Based on MEFV sequencing data and patients clinical ...
Programme: Cellular basis of diseases
Public web page: Not specified
Start date: 1st Sep 2021
End date: 31st Aug 2024
Together with the scientists at Agenus, a US-based biotech company specializing in innovative forms of cancer treatment, including the discovery and development of immuno-oncology therapies, ABI has formed a team of students and researchers to study cancer metastases and identify potential biomarkers and targets for cancer immunotherapies. This collaboration is also part of our long-term vision of supporting biotech developments in Armenia. The team discovers transcriptomics heterogeneity of Liver ...
Programme: Cancer Omics
Public web page: https://abi.am/research/research-labs/agenus-lab/
Start date: 21st Feb 2024
