Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians

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Abstract:

Mediterranean fever (FMF) is a genetically determined autoinflammatory disease transmitted mostly by an autosomal recessive mechanism and caused by point mutations of the MEFV (Mediterranean FeVer) gene. The aim of this study was to evaluate the expression of inflammasome genes (p65, Casp1, MEFV, and NLRP3) in patients with FMF compared to controls to understand the changes playing a key role in disease development. We found altered expression levels of the full-length MEFV isoform as well as Casp1 and p65 in FMF patients versus controls. This, once again, highlighted the significance of inflammasome genes in terms of FMF.

SEEK ID: https://armlifebank.am/publications/20

DOI: 10.3390/ijms252312958

Projects: Study of the molecular mechanisms of familial Mediterranean fever using ...

Publication type: Journal

Journal: International Journal of Molecular Sciences

Publisher: MDPI AG

Citation: International Journal of Molecular Sciences,25(23):12958

Date Published: 2nd Dec 2024

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Authors: Varduhi Hayrapetyan, Lana Karapetyan, Lilit Ghukasyan, Sofi Atshemyan, Hovsep Ghazaryan, Valentina Vardanyan, Vahan Mukuchyan, Arsen Arakelyan, Roksana Zakharyan

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Hayrapetyan, V., Karapetyan, L., Ghukasyan, L., Atshemyan, S., Ghazaryan, H., Vardanyan, V., Mukuchyan, V., Arakelyan, A., & Zakharyan, R. (2024). Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians. In International Journal of Molecular Sciences (Vol. 25, Issue 23, p. 12958). MDPI AG. https://doi.org/10.3390/ijms252312958
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Created: 6th Dec 2024 at 09:35

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