This project focuses on developing and applying machine learning (ML) methodologies to analyze complex omic datasets, including genomics, transcriptomics, proteomics, and metabolomics. By leveraging advanced ML techniques, the project aims to uncover novel biological insights, identify biomarkers, and enhance our understanding of molecular mechanisms underlying various diseases. The initiative is a collaborative effort maintained by the Institute of Molecular Biology NAS RA (IMB), the Armenian Bioinformatics Institute (ABI), and the Interdisciplinary Centre for Bioinformatics (IZBI) at the University of Leipzig. These institutions bring together expertise in bioinformatics, molecular biology, and computational sciences to advance the field of omic data analysis.
Programme: Bioinformatics Tools for Analysis of Big Genomic Data
SEEK ID: https://armlifebank.am/projects/11
Funding codes:- 22SC-BMBF-1C004
Public web page: Not specified
Organisms: No Organisms specified
ArmLifeBank PALs: No PALs for this Project
Project created: 7th Mar 2024
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Projects: Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue, Functional Genomics of Vine, Molecular Profiling of Cancer Metastases, Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Mental disorders and aging brain, Omics-Based Insights into Human Long-Term Exposure to Environmental Metals, Biological pathway activity analysis, ML approaches for omic data analysis, Tools for Telomere Biology, Armenian Wine Genome Program, Molecular characterization of cancers with long-read RNA sequencing, Low dose radiation risks: present research and future perspectives
Institutions: Institute of Molecular Biology NAS RA, Armenian Bioinformatics Institute

Projects: Functional Genomics of Vine, Molecular Profiling of Cancer Metastases, Biological pathway activity analysis, Mental disorders and aging brain, ML approaches for omic data analysis
Institutions: Armenian Bioinformatics Institute, Interdisciplinary Center for Bioinformatics (IZBI)

Projects: Biological pathway activity analysis, Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue, ML approaches for omic data analysis, Molecular characterization of cancers with long-read RNA sequencing
Institutions: Institute of Molecular Biology NAS RA

Expertise: Bioinformatics
Tools: Cytoscape, Genomics, Microarray analysis, Python, R, Single Cell analysis, Transcriptomics
Siras Hakobyan is currently a Junior Researcher and PhD student in the Research Group of Bioinformatics at the Institute of Molecular Biology NAS RA in Yerevan, Armenia. He received his Master's and Bachelor's degrees in Bioinformatics from Yerevan State University, completing his studies in 2018 and 2016. His PhD project focuses on pathway-centered analysis of high-throughput omics data, particularly examining pathway activity states in cancers based on pathway topology, gene expression, and ...
This Programme focuses on the development, implementation, and application of bioinformatics tools for the analysis of large-scale genomic datasets. It aims to facilitate the processing, integration, and interpretation of high-throughput sequencing data, including whole-genome, transcriptome, and epigenome analyses. The Programme encompasses computational approaches for variant discovery, gene expression profiling, network biology, and multi-omics data integration.
Projects: Biological pathway activity analysis, ML approaches for omic data analysis, Tools for Telomere Biology
Web page: Not specified
DigitalLife aims at bringing together complementary Armenian and German competence of the project partners in three major areas: omics bioinformatics for health with single-cell omics resolution, the establishment of infrastructure for genomic data collection, analysis, and sharing, and the Research School offering a qualification program for young scientists. The research tasks include the development of pathway analysis and machine learning methods and software for single-cell omic data analysis, ...
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Authors: A. Arakelyan, S. Avagyan, A. Kurnosov, T. Mkrtchyan, G. Mkrtchyan, R. Zakharyan, K. R. Mayilyan, H. Binder
Date Published: 17th Feb 2024
Publication Type: Journal
PubMed ID: 38368435
Citation: Schizophrenia (Heidelb). 2024 Feb 17;10(1):19. doi: 10.1038/s41537-024-00443-7.
Abstract (Expand)
Authors: Maria Nikoghosyan, Henry Loeffler-Wirth, Suren Davidavyan, Hans Binder, Arsen Arakelyan
Date Published: 27th Dec 2021
Publication Type: Journal
DOI: 10.3390/biomedinformatics2010004
Citation: BioMedInformatics,2(1):62-76
Abstract (Expand)
Authors: M. Nikoghosyan, M. Schmidt, K. Margaryan, H. Loeffler-Wirth, A. Arakelyan, H. Binder
Date Published: 17th Jul 2020
Publication Type: Journal
PubMed ID: 32709105
Citation: Genes (Basel). 2020 Jul 17;11(7):817. doi: 10.3390/genes11070817.
Abstract (Expand)
Authors: A. Arakelyan, L. Nersisyan, M. Nikoghosyan, S. Hakobyan, A. Simonyan, L. Hopp, H. Loeffler-Wirth, H. Binder
Date Published: 12th Dec 2019
Publication Type: Journal
PubMed ID: 31842375
Citation: Pharmaceutics. 2019 Dec 12;11(12):677. doi: 10.3390/pharmaceutics11120677.