Roksana Zakharyan

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About Roksana Zakharyan:

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SEEK ID: https://armlifebank.am/people/10

Location: Armenia

ORCID: Not specified

Joined: 14th Mar 2024

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Cellular basis of diseases

Cellular dysfunction, the fundamental basis of all human diseases, underpins the pathophysiology of numerous disorders. This program presents a overview of research initiatives focused on advancing human health through the development of diagnostic, preventive, and therapeutic strategies. These projects are conducted in collaboration with multiple research institutions and are supported by diverse grant funding mechanisms.

Projects: Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Development of induced pluripotent stem cells bank of patients with Familial Mediterranean Fever

Web page: Not specified

Genes, Environment and Chronic Diseases

This program is designed to encapsulate and facilitate research projects focusing on the intricate dynamics between genetic predispositions and environmental factors in the progression of chronic diseases, excluding cancer. This initiative aims to unravel the molecular mechanisms and pathways that underlie these diseases, thereby paving the way for targeted interventions and therapies.

Projects: Mental disorders and aging brain, Omics-Based Insights into Human Long-Term Exposure to Environmental Metals

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Mental disorders and aging brain

This project focuses on studies around brain disorders and ageing.

Programme: Genes, Environment and Chronic Diseases

Public web page: Not specified

Organisms: Human

Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics

In this project genetic engineering and functional genomics approaches will be used to describe molecular mechanisms of FMF. Using DNA/RNA samples obtained from FMF patients and healthy subjects MEFV nanopore gene sequencing will be performed to identify genetic variants and possibly find novel putative functional variants. The impact of genetic variants on transcriptome landscape will be studies by RNA-sequencing using nanopore sequencing device. Based on MEFV sequencing data and patients clinical ...

Programme: Cellular basis of diseases

Public web page: Not specified

Start date: 1st Sep 2021

End date: 31st Aug 2024

Organisms: Human

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Russian-Armenian University

Country: Armenia

City: Yerevan

Web page: https://www.rau.am

Showing 5 out of a possible 6 Publications Advanced Publications list for this Person with search and filtering

Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age.

Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue

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Abstract (Expand)

BACKGROUND: Long-term consumption of Western Diet (WD) is a well-established risk factor for the development of cardiovascular disease (CVD); however, there is a paucity of studies on the long-term …

Authors: A. Stepanyan, A. Brojakowska, R. Zakharyan, S. Hakobyan, S. Davitavyan, T. Sirunyan, G. Khachatryan, M. K. Khlgatian, M. Bisserier, S. Zhang, S. Sahoo, L. Hadri, A. Rai, V. N. S. Garikipati, A. Arakelyan, D. A. Goukassian

Date Published: 28th Dec 2024

Publication Type: Journal

PubMed ID: 39732652

Citation: Cardiovasc Diabetol. 2024 Dec 28;23(1):454. doi: 10.1186/s12933-024-02565-9.

Created: 11th Feb 2025 at 13:26

Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians

Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics

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Abstract (Expand)

Mediterranean fever (FMF) is a genetically determined autoinflammatory disease transmitted mostly by an autosomal recessive mechanism and caused by point mutations of the MEFV (Mediterranean FeVer) …

Authors: Varduhi Hayrapetyan, Lana Karapetyan, Lilit Ghukasyan, Sofi Atshemyan, Hovsep Ghazaryan, Valentina Vardanyan, Vahan Mukuchyan, Arsen Arakelyan, Roksana Zakharyan

Date Published: 2nd Dec 2024

Publication Type: Journal

DOI: 10.3390/ijms252312958

Citation: International Journal of Molecular Sciences,25(23):12958

Created: 6th Dec 2024 at 09:35

Genewise detection of variants in MEFV gene using nanopore sequencing

Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics

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Abstract (Expand)

Mediterranean Fever (FMF) is a genetic disorder with complex inheritance patterns and genotype-phenotype associations, and it is highly prevalent in Armenia. FMF typically follows an autosomal recessive …

Authors: Lilit Ghukasyan, Gisane Khachatryan, Tamara Sirunyan, Arpine Minasyan, Siras Hakobyan, Andranik Chavushyan, Varduhi Hayrapetyan, Hovsep Ghazaryan, Gevorg Martirosyan, Gohar Mkrtchyan, Valentina Vardanyan, Vahan Mukuchyan, Ashot Davidyants, Roksana Zakharyan, Arsen Arakelyan

Date Published: 29th Nov 2024

Publication Type: Journal

DOI: 10.3389/fgene.2024.1493295

Citation: Frontiers in Genetics,15

Created: 6th Dec 2024 at 09:33

Generation of iPSCs from a Patient with the M694V Mutation in the MEFV Gene Associated with Familial Mediterranean Fever and Their Differentiation into Macrophages

Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics

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Abstract (Expand)

Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by inherited mutations in the MEFV (Mediterranean FeVer) gene, located on chromosome 16 (16p13.3) and encoding the pyrin protein. …

Authors: Elena V. Grigor’eva, Lana V. Karapetyan, Anastasia A. Malakhova, Sergey P. Medvedev, Julia M. Minina, Varduhi H. Hayrapetyan, Valentina S. Vardanyan, Suren M. Zakian, Arsen Arakelyan, Roksana Zakharyan

Date Published: 1st Jun 2024

Publication Type: Journal

DOI: 10.3390/ijms25116102

Citation: International Journal of Molecular Sciences,25(11):6102

Created: 6th Dec 2024 at 09:17

Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder.

Mental disorders and aging brain, ML approaches for omic data analysis

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Abstract (Expand)

The molecular events underlying the development, manifestation, and course of schizophrenia, bipolar disorder, and major depressive disorder span from embryonic life to advanced age. However, little …

Authors: A. Arakelyan, S. Avagyan, A. Kurnosov, T. Mkrtchyan, G. Mkrtchyan, R. Zakharyan, K. R. Mayilyan, H. Binder

Date Published: 17th Feb 2024

Publication Type: Journal

PubMed ID: 38368435

Citation: Schizophrenia (Heidelb). 2024 Feb 17;10(1):19. doi: 10.1038/s41537-024-00443-7.

Created: 28th Apr 2024 at 14:09

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Patient-specific induced pluripotent stem cells (iPSCs)

Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics

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Patient-specific induced pluripotent stem cells (iPSCs) are reprogrammed somatic cells derived from individual patients through the expression of key transcription factors (e.g., OCT4, SOX2, KLF4, and c-MYC). These cells exhibit pluripotency, allowing them to differentiate into various cell types and serve as in vitro models for studying disease mechanisms, drug screening, and regenerative medicine.

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Created: 5th Feb 2025 at 06:34

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