Ani Stepanyan

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About Ani Stepanyan:

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SEEK ID: https://armlifebank.am/people/6

Location: Armenia

ORCID: https://orcid.org/0000-0001-8564-8532

Joined: 14th Mar 2024

Expertise: Not specified

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Genes, Environment and Chronic Diseases

This program is designed to encapsulate and facilitate research projects focusing on the intricate dynamics between genetic predispositions and environmental factors in the progression of chronic diseases, excluding cancer. This initiative aims to unravel the molecular mechanisms and pathways that underlie these diseases, thereby paving the way for targeted interventions and therapies.

Projects: Mental disorders and aging brain, Omics-Based Insights into Human Long-Term Exposure to Environmental Metals

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Omics-Based Insights into Human Long-Term Exposure to Environmental Metals

Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The human epidemiologic and the toxicologic animal model studies provide strong evidence of metal exposure related DNA methylation changes, and, consequently alterations in gene expression, in metabolic, genetic and signal transduction pathways and their functions. The current study is designed to investigate genome wide DNA methylation and transcriptomic changes induced by human chronic ...

Programme: Genes, Environment and Chronic Diseases

Public web page: Not specified

Start date: 1st Feb 2020

Organisms: Human

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Institute of Molecular Biology NAS RA

Country: Armenia

City: Yerevan

Web page: https://molbiol.sci.am

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Transcriptome alterations in long-term mining region residents: Insights into immune response and molecular pathways.

Omics-Based Insights into Human Long-Term Exposure to Environmental Metals

Abstract (Expand)

Pollution with metals and metalloids is a global problem that adversely affects human health and environment. Although several studies have reported gene expression changes in response to human exposures …

Authors: A. Stepanyan, A. Arakelyan, J. Schug

Date Published: 24th Mar 2025

Publication Type: Journal

PubMed ID: 40023890

Citation: Environ Int. 2025 Mar;197:109344. doi: 10.1016/j.envint.2025.109344. Epub 2025 Feb 21.

Created: 10th Apr 2025 at 12:12

Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age.

Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue

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Abstract (Expand)

BACKGROUND: Long-term consumption of Western Diet (WD) is a well-established risk factor for the development of cardiovascular disease (CVD); however, there is a paucity of studies on the long-term …

Authors: A. Stepanyan, A. Brojakowska, R. Zakharyan, S. Hakobyan, S. Davitavyan, T. Sirunyan, G. Khachatryan, M. K. Khlgatian, M. Bisserier, S. Zhang, S. Sahoo, L. Hadri, A. Rai, V. N. S. Garikipati, A. Arakelyan, D. A. Goukassian

Date Published: 28th Dec 2024

Publication Type: Journal

PubMed ID: 39732652

Citation: Cardiovasc Diabetol. 2024 Dec 28;23(1):454. doi: 10.1186/s12933-024-02565-9.

Created: 11th Feb 2025 at 13:26

PSF toolkit: an R package for pathway curation and topology-aware analysis.

Biological pathway activity analysis

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Abstract (Expand)

Most high throughput genomic data analysis pipelines currently rely on over-representation or gene set enrichment analysis (ORA/GSEA) approaches for functional analysis. In contrast, topology-based … pathway analysis methods, which offer a more biologically informed perspective by incorporating interaction and topology information, have remained underutilized and inaccessible due to various limiting factors. These methods heavily rely on the quality of pathway topologies and often utilize predefined topologies from databases without assessing their correctness. To address these issues and make topology-aware pathway analysis more accessible and flexible, we introduce the PSF (Pathway Signal Flow) toolkit R package. Our toolkit integrates pathway curation and topology-based analysis, providing interactive and command-line tools that facilitate pathway importation, correction, and modification from diverse sources. This enables users to perform topology-based pathway signal flow analysis in both interactive and command-line modes. To showcase the toolkit's usability, we curated 36 KEGG signaling pathways and conducted several use-case studies, comparing our method with ORA and the topology-based signaling pathway impact analysis (SPIA) method. The results demonstrate that the algorithm can effectively identify ORA enriched pathways while providing more detailed branch-level information. Moreover, in contrast to the SPIA method, it offers the advantage of being cut-off free and less susceptible to the variability caused by selection thresholds. By combining pathway curation and topology-based analysis, the PSF toolkit enhances the quality, flexibility, and accessibility of topology-aware pathway analysis. Researchers can now easily import pathways from various sources, correct and modify them as needed, and perform detailed topology-based pathway signal flow analysis. In summary, our PSF toolkit offers an integrated solution that addresses the limitations of current topology-based pathway analysis methods. By providing interactive and command-line tools for pathway curation and topology-based analysis, we empower researchers to conduct comprehensive pathway analyses across a wide range of applications.

Authors: S. Hakobyan, A. Stepanyan, L. Nersisyan, H. Binder, A. Arakelyan

Date Published: 8th Sep 2023

Publication Type: Journal

PubMed ID: 37680201

Citation: Front Genet. 2023 Aug 23;14:1264656. doi: 10.3389/fgene.2023.1264656. eCollection 2023.

Created: 6th Mar 2024 at 19:17, Last updated: 3rd Apr 2025 at 08:38

Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis.

Omics-Based Insights into Human Long-Term Exposure to Environmental Metals

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Abstract (Expand)

BACKGROUND: Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the type and level of metal exposure and epigenetic …

Authors: A. Stepanyan, A. Petrackova, S. Hakobyan, J. Savara, S. Davitavyan, E. Kriegova, A. Arakelyan

Date Published: 7th Aug 2023

Publication Type: Journal

PubMed ID: 37550793

Citation: Clin Epigenetics. 2023 Aug 7;15(1):126. doi: 10.1186/s13148-023-01536-3.

Created: 6th Mar 2024 at 18:15

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