Ani Stepanyan

Background: Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the type, timing and level of metal exposure and DNA methylation is not yet clear. The human epidemiologic and the toxicologic animal model studies provide strong evidence of metal exposure related DNA methylation changes, and, consequently alterations in gene expression, in metabolic, genetic and signal transduction pathways and their functions. ...