The effects of space radiation on the transcriptome of heart right ventricle tissue

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Abstract:

Deep space represents a challenging environment for human exploration and can be accompanied by harmful health-related risks. We aimed to assess the effect of simplified galactic cosmic ray simulated (simGCRsim) and gamma (γ) ionizing radiation (IR) on transcriptome changes in right ventricular (RV) tissue after a single low dose (0.5 Gy, 500 MeV/nucleon) full body exposure in C57BL/6J male and female mice. In females, no differentially expressed genes (DEGs) and only 2 upregulated genes in males exposed to γ-IR were revealed. In contrast, exposure to simGCRsim-IR resulted in 4 DEGs in females and 371 DEGs in males, suggesting longer-lasting and sex-biased DEGs after simGCRsim-IR. Overrepresentation analysis of DEGs in simGCRsim-IR males revealed significant enrichment in pathways related to muscle contraction, hypertrophic cardiomyopathy, oxytocin release, the regulation of cytoskeleton, and genes associated with Alzheimer’s, Huntington’s, and Parkinson’s diseases. Our results suggested the RV transcriptome exhibits distinct responses after exposure based on both the IR and sex.

SEEK ID: https://armlifebank.am/publications/35

DOI: 10.1038/s41526-025-00506-8

Projects: Sex-specific differences in long-term gamma and simGCRsim-associated alt...

Publication type: Journal

Journal: npj Microgravity

Publisher: Springer Science and Business Media LLC

Citation: npj Microgravity,11(1)

Date Published: 21st Jul 2025

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Authors: Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Malik Bisserier, Shihong Zhang, Mary K. Khlgatian, Amit Kumar Rai, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Susmita Sahoo, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A. Goukassian

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Zakharyan, R., Hakobyan, S., Brojakowska, A., Bisserier, M., Zhang, S., Khlgatian, M. K., Rai, A. K., Davitavyan, S., Stepanyan, A., Sirunyan, T., Khachatryan, G., Sahoo, S., Garikipati, V. N. S., Arakelyan, A., & Goukassian, D. A. (2025). The effects of space radiation on the transcriptome of heart right ventricle tissue. In npj Microgravity (Vol. 11, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41526-025-00506-8
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Created: 18th Aug 2025 at 09:04

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