Patient-specific induced pluripotent stem cells (iPSCs)
View samplesPatient-specific induced pluripotent stem cells (iPSCs) are reprogrammed somatic cells derived from individual patients through the expression of key transcription factors (e.g., OCT4, SOX2, KLF4, and c-MYC). These cells exhibit pluripotency, allowing them to differentiate into various cell types and serve as in vitro models for studying disease mechanisms, drug screening, and regenerative medicine.
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Created: 5th Feb 2025 at 06:34
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Cellular dysfunction, the fundamental basis of all human diseases, underpins the pathophysiology of numerous disorders. This program presents a overview of research initiatives focused on advancing human health through the development of diagnostic, preventive, and therapeutic strategies. These projects are conducted in collaboration with multiple research institutions and are supported by diverse grant funding mechanisms.
Projects: Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Development of induced pluripotent stem cells bank of patients with Familial Mediterranean Fever
Web page: Not specified
In this project genetic engineering and functional genomics approaches will be used to describe molecular mechanisms of FMF. Using DNA/RNA samples obtained from FMF patients and healthy subjects MEFV nanopore gene sequencing will be performed to identify genetic variants and possibly find novel putative functional variants. The impact of genetic variants on transcriptome landscape will be studies by RNA-sequencing using nanopore sequencing device. Based on MEFV sequencing data and patients clinical ...
Programme: Cellular basis of diseases
Public web page: Not specified
Start date: 1st Sep 2021
End date: 31st Aug 2024
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
Type: Patient-specific induced pluripotent stem cells (iPSCs)
Creators: Arsen Arakelyan, Lana Karapetyan, Roksana Zakharyan
Submitter: Arsen Arakelyan
