Bioinformatics Tools for Analysis of Big Genomic Data

This project focuses on developing and applying machine learning (ML) methodologies to analyze complex omic datasets, including genomics, transcriptomics, proteomics, and metabolomics. By leveraging advanced ML techniques, the project aims to uncover novel biological insights, identify biomarkers, and enhance our understanding of molecular mechanisms underlying various diseases. The initiative is a collaborative effort maintained by the Institute of Molecular Biology NAS RA (IMB), ...

DigitalLife aims at bringing together complementary Armenian and German competence of the project partners in three major areas: omics bioinformatics for health with single-cell omics resolution, the establishment of infrastructure for genomic data collection, analysis, and sharing, and the Research School offering a qualification program for young scientists. The research tasks include the development of pathway analysis and machine learning methods and software for single-cell omic data analysis, ...

This is a supplementary dataset with raw data, scripts, and complete analysis results for the paper "Supervised projection of high-dimensional genome-wide expression on SOM transcriptome landscapes".

The archive contains three folders:

1. "Simdata" folder contains data, scripts, and results of performance evaluation of extension SOM and supervised SOM with simulated data.

2. "IBD" - folder contains data, scripts, and results of analysis of Inflammatory bowel disease datasets.

3. "BC" - folder ...

This is the submission accompanying the "Telomere Maintenance Pathways in Lower-Grade Gliomas: Insights from Genetic Subtypes and Telomere Length Dynamics" paper.

The dataset contains the TCGA and CGGA LGG

The dataset is organized as follows:

Folder "CGGA_LGG_IDH_subtype_mean_vis" - The CGGAL GG data IDH subtype pathway visualization and CSV data. Folder "Long_Short_telomeres_path_vis" - The TCGA LGG data ALT and TEL pathway visualization for Long and Short telomeres mean values. Folder ...

oposSOM is a comprehensive, machine learning based open-source data analysis software combining functionalities such as diversity analyses, biomarker selection, function mining, and visualization. These functionalities are now available as interactive web-browser application for a broader user audience interested in extracting detailed information from high-throughput omics data sets pre-processed by oposSOM. It enables interactive browsing of single-gene and gene set profiles, of molecular ...

The Pathway Signal Flow (PSF) toolkit is an R package designed for pathway editing and signal flow analysis. It enables users to perform PSF analysis on functional -omics data, facilitating the study of signaling pathways in various biological contexts.

Key Features:

• Pathway Editing: Allows customization and editing of biological pathways to suit specific research needs.

• Signal Flow Calculation: Computes signal flow within pathways based on gene expression data, aiding in the ...

KEGG pathway database is a collection of manually drawn pathway maps representing current knowledge on molecular interaction and reaction networks, accompanied with KGML (KEGG pathway xml format) files for automatic computational analyses and modeling of metabolic and signaling networks. In a KGML file the pathway is represented as a graph object with entry elements (gene products, compounds, pathways) as its nodes, and relations between elements as edges. However, in most cases there is a lack ...