The Effects of Space Radiation on the Transcriptome of Heart Right Ventricle Tissue Version 1
External LinkThe cited in the main text supporting Supplementary Figures and Data can be downloaded at https://doi.org/10.5281/zenodo.15624414 and the datasets can be downloaded using the following accession numbers GSE272168 for the left ventricle RNAseq dataset and GSE300189 for the right ventricle RNAseq dataset. Any additional datasets used and/or analyzed in this study are available from the corresponding authors upon request at the reasonable timeframe. Preprocessed raw gene expression count matrices used to perform the analysis of this study can be accessed from the GitHub repository at this link: https://github.com/hakobyansiras/RV_diff_exp_analysis.
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Created: 18th Aug 2025 at 09:10
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Version 1 (earliest) Created 18th Aug 2025 at 09:10 by Lana Karapetyan
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Projects: Biological pathway activity analysis, Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue, ML approaches for omic data analysis, Molecular characterization of cancers with long-read RNA sequencing
Institutions: Institute of Molecular Biology NAS RA
https://orcid.org/0000-0002-6875-2482
Siras Hakobyan is currently a Junior Researcher and PhD student in the Research Group of Bioinformatics at the Institute of Molecular Biology NAS RA in Yerevan, Armenia. He received his Master's and Bachelor's degrees in Bioinformatics from Yerevan State University, completing his studies in 2018 and 2016. His PhD project focuses on pathway-centered analysis of high-throughput omics data, particularly examining pathway activity states in cancers based on pathway topology, gene expression, and ...
Projects: Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Development of induced pluripotent stem cell bank of patients with Familial Mediterranean Fever, Molecular Profiling of Cancer Metastases, Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue, Molecular characterization of cancers with long-read RNA sequencing, ML approaches for omic data analysis, Mental disorders and aging brain, Armenian Wine Genome Program, Functional Genomics of Vine, COVID-19, Genetic History of Armenians, Molecular epidemiology of multi-drug resistance, Multi-Omics Molecular Diversity of Cancers, Third International Congress "CRISPR-2025", International Summit in Immuno-Oncology, Low dose radiation risks: present research and future perspectives
Institutions: Russian-Armenian University, Institute of Molecular Biology NAS RA
https://orcid.org/0009-0009-7992-1366
Principal Investigator: Prof. David Goukassian
University: Icahn School of Medicine at Mount Sinai
Research team: Recruitment in progress
Duration:2023-2027
Hosting partner: Institute of Molecular Biology NAS RA (IMB)
Project Importance The high likelihood of developing genomic instability due to exposure to ionizing radiation suggests that exposure can cause DNA damage to hematopoietic stem cells (HSCs), promoting the development of somatic mutations that can lead to aberrant clonal events. ...
Web page: https://fast.foundation/en/program/847/2022/new_tab/6586/7014
Space radiation (IR) from Solar Particle Events (SPE) and Galactic Cosmic Rays (GCR), also known as high charge and energy (HZE) IR, is a primary risk associated with deep-space missions. There are limited animal and human studies on the risk of cardiovascular disease (CVD) development due to space-IR. The cardiac effects induced by space-type IR, specifically simplified GCR simulated (simGCRsim)-IR, are yet to be discovered. We hypothesized that gamma (γ) and simGCRsim IR-induced biological ...
Programme: Space Radiobiology
Public web page: Not specified
Start date: 1st Jul 2023
End date: 30th Jun 2027
Abstract (Expand)
Authors: Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Malik Bisserier, Shihong Zhang, Mary K. Khlgatian, Amit Kumar Rai, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Susmita Sahoo, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A. Goukassian
Date Published: 21st Jul 2025
Publication Type: Journal
