Space flight associated changes in astronauts’ plasma‐derived small extracellular vesicle microRNA: Biomarker identification

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Abstract:

Dear Editor, This pilot study suggests relatively short (median 12 days long) low-Earth orbit (LEO) spaceflight induces changes in circulating plasma small extracellular vesicle (sEV) microRNA expression. Normalization of small RNA sequencing (sRNAseq) data and quantitative polymerase chain reaction (qPCR) validation confirmed miR-4732-3p is significantly upregulated up to 3 days post-landing, and enrichment analysis suggests this miRNA is expressed in various central nervous system tissues and hematopoietic cells and may be linked to different organ disorders.

SEEK ID: https://armlifebank.am/publications/106

DOI: 10.1002/ctm2.845

Projects: Sex-specific differences in long-term gamma and simGCRsim-associated alt...

Publication type: Journal

Journal: Clinical and Translational Medicine

Publisher: Wiley

Citation: Clinical and Translational Medicine,12(6)

Date Published: 2nd Jun 2022

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Authors: David Goukassian, Arsen Arakelyan, Agnieszka Brojakowska, Malik Bisserier, Siras Hakobyan, Lahouaria Hadri, Amit Kumar Rai, Angela Evans, Aimy Sebastian, May Truongcao, Carolina Gonzalez, Anamika Bajpai, Zhongjian Cheng, Praveen Kumar Dubey, Sankar Addya, Paul Mills, Kenneth Walsh, Raj Kishore, Matt Coleman, Venkata Naga Srikanth Garikipati

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Lana Karapetyan

Citation

Goukassian, D., Arakelyan, A., Brojakowska, A., Bisserier, M., Hakobyan, S., Hadri, L., Rai, A. K., Evans, A., Sebastian, A., Truongcao, M., Gonzalez, C., Bajpai, A., Cheng, Z., Dubey, P. K., Addya, S., Mills, P., Walsh, K., Kishore, R., Coleman, M., & Garikipati, V. N. S. (2022). Space flight associated changes in astronauts’ plasma‐derived small extracellular vesicle microRNA: Biomarker identification. In Clinical and Translational Medicine (Vol. 12, Issue 6). Wiley. https://doi.org/10.1002/ctm2.845

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Created: 27th Aug 2025 at 16:08

Space flight associated changes in astronauts’ plasma‐derived small extracellular vesicle microRNA: Biomarker identification

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