Genomic Instability and Clonal Hematopoiesis in the Deep-Space Environment: The Role of Sex-Chromosome Asymmetry and High-LET Radiation

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Abstract:

This paper examines how deep-space conditions in the Artemis program, including radiation, microgravity, and other stressors affect genomic stability in blood-forming cells, with a focus on clonal hematopoiesis and sex-specific differences in DNA repair and mutation risk. Studies show space conditions promote mutations in hematopoietic stem cells, with sex-specific effects: males are more vulnerable to Y chromosome loss and structural damage, while females may experience increased epigenetic instability despite protective redundancy from the X chromosome; these risks are amplified by combined stressors like radiation, oxidative stress, and circadian disruption. Sex chromosome differences play a key role in radiation-induced mutations and clonal expansion, highlighting the need for personalized, sex-specific medical monitoring and countermeasures rather than a uniform approach for astronauts on long-duration missions.

SEEK ID: https://armlifebank.am/publications/130

DOI: 10.1007/s40778-026-00255-8

Projects: Sex-specific differences in long-term gamma and simGCRsim-associated alt...

Publication type: Journal

Journal: Current Stem Cell Reports

Publisher: Springer Science and Business Media LLC

Citation: Current Stem Cell Reports,12(1)

Date Published: 23rd Apr 2026

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Authors: Roksana Zakharyan, Ani Stepanyan, Arpine Minasyan, Suren Davitavyan, Gisane Lazaryan, Siras Hakobyan, Agnieszka Brojakowska, Malik Bisserier, Susmita Sahoo, Shihong Zhang, Venkata Naga Srikanth Garikipati, Mary K. Khlgatian, Arsen Arakelyan, David A. Goukassian

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Lana Karapetyan

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Zakharyan, R., Stepanyan, A., Minasyan, A., Davitavyan, S., Lazaryan, G., Hakobyan, S., Brojakowska, A., Bisserier, M., Sahoo, S., Zhang, S., Garikipati, V. N. S., Khlgatian, M. K., Arakelyan, A., & Goukassian, D. A. (2026). Genomic Instability and Clonal Hematopoiesis in the Deep-Space Environment: The Role of Sex-Chromosome Asymmetry and High-LET Radiation. In Current Stem Cell Reports (Vol. 12, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1007/s40778-026-00255-8

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Created: 29th Apr 2026 at 14:54

Genomic Instability and Clonal Hematopoiesis in the Deep-Space Environment: The Role of Sex-Chromosome Asymmetry and High-LET Radiation

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