Life long effects of radiation and high fat dieat on the mouse left ventricular tissue Version 1
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Created: 11th Feb 2025 at 13:41
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Version 1 (earliest) Created 11th Feb 2025 at 13:41 by Arsen Arakelyan
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Projects: Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue, Functional Genomics of Vine, Molecular Profiling of Cancer Metastases, Epigenetic influence of human long-term environmental exposure to metals, Biological pathway activity analysis, ML approaches for omic data analysis, Tools for Telomere Biology, Mental disorders and aging brain, Armenian Wine Genome Program, Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Molecular characterization of cancers with long-read RNA sequencing
Institutions: Institute of Molecular Biology NAS RA, Armenian Bioinformatics Institute
https://orcid.org/0000-0002-6851-1056
Siras Hakobyan is currently a Junior Researcher and PhD student in the Research Group of Bioinformatics at the Institute of Molecular Biology NAS RA in Yerevan, Armenia. He received his Master's and Bachelor's degrees in Bioinformatics from Yerevan State University, completing his studies in 2018 and 2016. His PhD project focuses on pathway-centered analysis of high-throughput omics data, particularly examining pathway activity states in cancers based on pathway topology, gene expression, and ...
Principal Investigator: Prof. David Goukassian
University: Icahn School of Medicine at Mount Sinai
Research team: Recruitment in progress
Duration:2023-2027
Hosting partner: Institute of Molecular Biology NAS RA (IMB)
Project Importance The high likelihood of developing genomic instability due to exposure to ionizing radiation suggests that exposure can cause DNA damage to hematopoietic stem cells (HSCs), promoting the development of somatic mutations that can lead to aberrant clonal events. ...
Web page: https://fast.foundation/en/program/847/2022/new_tab/6586/7014
Space radiation (IR) from Solar Particle Events (SPE) and Galactic Cosmic Rays (GCR), also known as high charge and energy (HZE) IR, is a primary risk associated with deep-space missions. There are limited animal and human studies on the risk of cardiovascular disease (CVD) development due to space-IR. The cardiac effects induced by space-type IR, specifically simplified GCR simulated (simGCRsim)-IR, are yet to be discovered. We hypothesized that gamma (γ) and simGCRsim IR-induced biological ...
Programme: Space Radiobiology
Public web page: Not specified
Start date: 1st Jul 2023
End date: 30th Jun 2027
Abstract (Expand)
Authors: A. Stepanyan, A. Brojakowska, R. Zakharyan, S. Hakobyan, S. Davitavyan, T. Sirunyan, G. Khachatryan, M. K. Khlgatian, M. Bisserier, S. Zhang, S. Sahoo, L. Hadri, A. Rai, V. N. S. Garikipati, A. Arakelyan, D. A. Goukassian
Date Published: 28th Dec 2024
Publication Type: Journal
