FEMALE AND MALE HEARTS RESPOND DIFFERENTLY TO SAME DOSES OF GAMMA AND simGCRsim RADIATION – SEX MATTERS Version 1
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Created: 16th Feb 2024 at 19:49
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Version 1 (earliest) Created 16th Feb 2024 at 19:49 by Arsen Arakelyan
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Projects: Sex-specific differences in long-term gamma and simGCRsim-associated alterations in deferential gene expression in the heart tissue, Functional Genomics of Vine, Molecular Profiling of Cancer Metastases, Omics-Based Insights into Human Long-Term Exposure to Environmental Metals, Biological pathway activity analysis, ML approaches for omic data analysis, Tools for Telomere Biology, Mental disorders and aging brain, Armenian Wine Genome Program, Study of the molecular mechanisms of familial Mediterranean fever using genetic engineering and functional genomics, Molecular characterization of cancers with long-read RNA sequencing, Low dose radiation risks: present research and future perspectives, Third International Congress "CRISPR-2025", International Summit in Immuno-Oncology
Institutions: Institute of Molecular Biology NAS RA, Armenian Bioinformatics Institute
https://orcid.org/0000-0002-6851-1056
Principal Investigator: Prof. David Goukassian
University: Icahn School of Medicine at Mount Sinai
Research team: Recruitment in progress
Duration:2023-2027
Hosting partner: Institute of Molecular Biology NAS RA (IMB)
Project Importance The high likelihood of developing genomic instability due to exposure to ionizing radiation suggests that exposure can cause DNA damage to hematopoietic stem cells (HSCs), promoting the development of somatic mutations that can lead to aberrant clonal events. ...
Web page: https://fast.foundation/en/program/847/2022/new_tab/6586/7014
Space radiation (IR) from Solar Particle Events (SPE) and Galactic Cosmic Rays (GCR), also known as high charge and energy (HZE) IR, is a primary risk associated with deep-space missions. There are limited animal and human studies on the risk of cardiovascular disease (CVD) development due to space-IR. The cardiac effects induced by space-type IR, specifically simplified GCR simulated (simGCRsim)-IR, are yet to be discovered. We hypothesized that gamma (γ) and simGCRsim IR-induced biological ...
Programme: Space Radiobiology
Public web page: Not specified
Start date: 1st Jul 2023
End date: 30th Jun 2027
